An October 2023 study by a cohort of institutions said
"A 12% reduction in calorie intake is very modest,"
"This kind of small reduction in calorie intake is doable and may make a big difference in your health."
"Since inflammation and aging are strongly coupled, calorie restriction represents a powerful approach to preventing the pro-inflammatory state that is developed by many older people,"
Reference
Das JK, et al. Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study. Aging Cell. 2023; Oct 12:e13963. doi: 10.1111/acel.13963.