Cranberries, Microbiota and Metabolic Disease

An April 2024 study by Université Laval said,

• “… these bacteria are stimulated by dietary fibre consumption. We observed the same effect with cranberry extract with a dose almost 20 times lower,"

• “[The] diet alters the microbiota, causes inflammation of the mucosa, and compromises the integrity of the intestinal barrier, which plays a crucial role in protecting the body from bacteria present in the gut. Alteration of the intestinal barrier allows the passage of lipopolysaccharides (LPS) derived from the intestinal microbiota, known as metabolic endotoxemia, and is a crucial factor in the onset and progression of inflammation and metabolic diseases,”

• “The constant inflammation that results from the presence of LPS in the body can lead to several chronic diseases, including diabetes, and cardiovascular disease,”

metabolic health and calories

A May 2021 study by the Nutrient Sensing and Adipocyte Signaling Laboratory at Pennington Biomedical Research Center

• "We've known for years that restricting the amino acid methionine in the diet produces immediate and lasting improvements in nearly every biomarker of metabolic health," 

• "The problem is that methionine-restricted diets have been difficult to implement because they taste so bad."

• "A diet that offsets all the major components of metabolic disease would have an enormous impact on the nation's health, and the world's," 

• "Calorie restriction is an effective weight-management tool. But for most people it is also very, very difficult to follow long-term," 

• "This struggle is one of the major reasons our scientists explore every avenue to find solutions to the obesity epidemic.”

The Soleus muscle, glucose and fat burning, metabolism while sitting

A September 2022 study by the University of Houston on the soleus muscle in the calf and its development of  the “soleus pushup” (SPU) which effectively elevates muscle metabolism for hours, even when sitting.  The researchers said, 

• “We never dreamed that this muscle has this type of capacity. It's been inside our bodies all along, but no one ever investigated how to use it to optimize our health, until now,” 

• “When activated correctly, the soleus muscle can raise local oxidative metabolism to high levels for hours, not just minutes, and does so by using a different fuel mixture.”  

• “The soleus’ lower-than-normal reliance on glycogen helps it work for hours effortlessly without fatiguing during this type of muscle activity, because there is a definite limit to muscular endurance caused by glycogen depletion,”

•  “As far as we know, this is the first concerted effort to develop a specialized type of contractile activity centered around optimizing human metabolic processes.” 

Eureka notes

“The Soleus Pushup 

While seated with feet flat on the floor and muscles relaxed, the heel rises while the front of the foot stays put. When the heel gets to the top of its range of motion, the foot is passively released to come back down. The aim is to simultaneously shorten the calf muscle while the soleus is naturally activated by its motor neurons.”

The University of Houston added, 

• “The soleus pushup looks simple from the outside, but sometimes what we see with our naked eye isn't the whole story. It’s a very specific movement that right now requires wearable technology and experience to optimize the health benefits,” 

• “All of the 600 muscles combined normally contribute only about 15% of the whole-body oxidative metabolism in the three hours after ingesting carbohydrate. Despite the fact that the soleus is only 1% the body weight, it is capable of raising its metabolic rate during SPU contractions to easily double, even sometimes triple, the whole-body carbohydrate oxidation.” 

• “We are unaware of any existing or promising pharmaceuticals that come close to raising and sustaining whole-body oxidative metabolism at this magnitude.” 

Muscle Repair and Glucose

An April 2021 study by Tokyo Metropolitan University found that skeletal muscle satellite cells perform better in environments that are low in glucose. 

The researchers noticed also that high glucose had an adverse effect.

Intermittent Fasting and Belly Fat

A March 2021 study by the University of Sydney on mice found that, 

• "While most people would think that all fat tissue is the same, in fact, the location makes a big difference,"

• "Our data show both visceral and subcutaneous fat undergo dramatic changes during intermittent fasting,"

• "visceral [belly] fat can adapt to repeated fasting bouts and protect its energy store,"

• "This type of adaptation may be the reason why visceral fat can be resistant to weight loss after long periods of dieting."

metabolic pathways and disease

A March 2021 study headed up by Dr. Claudia Langenberg, looked at a number of unassociated metabolic processes linked to various diseases.

"We wanted to know whether there are certain markers in the blood that indicate a risk, not only for one but for several diseases at the same time," 

"We found, for example, that an increased concentration of the sugar-like molecule N-acetylneuraminate increased the risk of no less than 14 diseases," 

"Gamma-glutamylglycine, on the other hand, is exclusively associated with the occurrence of diabetes. Other members of the same molecular groups simultaneously increase the risk of liver and heart disease." 

"Overall, we observed that two-thirds of the molecules are associated with the occurrence of more than one disease. This is in line with the fact that patients often develop a range of diseases in the course of their lives. If we succeed in influencing these key factors, this could make it possible to counter multiple diseases simultaneously."

Seed Oils

Polyunsaturated Fats

Any Refined

Any Bleached

Any Deodorized

• Soy oil

• Sesame oil

• Sunflower oil

• Safflower oil

• Canola oil

• Rapeseed oil

• Corn oil

• Cottonseed oil

• Hydrogenated oil

• Refined Palm oil

• Grapeseed oil

• Ricebran oil

Trans Fats

• label says “hydrogentated”

• Fake whipped cream

• Fake butter spreads

• Store-bought pastries

• Chicken nuggets

• Margarine

• Shortening

• Restaurant fried foods

• Most chips

• Most crackers

• Most protein bars

• Most salad dressings

• Most mayonaisse

• Most granola

• Most cereal

ReFined Fats

• Refined peanut oil

• Refined avocado oil

• Refined coconut oil

Caution with heat

• Walnut oil

• Flax oil

• Sesame

• Walnuts

• Seeds

• Fatty fish

• Artisanal grapeseed

Source

Deep Nutrition Dr Catherine Shanahan

Chronobiology, the liver, circadian rhythms and position

A new January 2021 study by the Ecole Polytechnique Federale de Lausane in the field of chronobiology sees Western medicine finding the first steps on its way towards a concept known for many hundreds of years in the field of Chinese Medicine as to time and the organs of the body. And in Unani Tibb medicine regarding time and position of the liver.

The study found that, “many of the liver's genes seem to be both zonated and rhythmic, meaning that they are regulated by both their location in the liver and the time of the day. These dually regulated genes are mostly linked to key functions of the liver, e.g. the metabolism of lipids, carbohydrates, and amino acids,”

"The work reveals a richness of space-time gene expression dynamics of the liver, and shows how compartmentalization of liver function in both space and time is hallmark of metabolic activity in the mammalian liver,"

Alternating Keto Diet – “Starving-Not Starving”

A January 2020 study (on mice) by Yale University found mixed results by following a ketogenic diet.  Short term health benefits were followed by some negative effects.  There appears to be some benefit in lowering inflammation and reducing the risk of diabetes. Researchers said, “Obesity and type 2 diabetes are lifestyle diseases … Diet allows people a way to be in control … Our findings highlight the interplay between metabolism and the immune system, and how it coordinates maintenance of healthy tissue function,"

Bread Products – the Glycemic Index (GI)

This is a way of measuring how the food that you eat affects the amount of sugar in your blood.  This is important for a number of reasons.

A food with a GI value of 55 or less is labelled “Low GI”.  The food will have a slower, longer impact on you, energy-wise.  High GI foods (those with a GI above 70) will be used by your body before any stored energy like body fat. And this may make weight loss more difficult.

French Baguette - 95

Bagel - 72

White Bread - 71

Croissant - 67

Wholemeal Rye - 62

Hamburger Bun - 61

Pitta - 57

__________________________

Sourdough Wheat - 54

Whole Wheat - 49

Sourdough Rye - 48

Pumpernickel - 46

Heavy Mixed Grain - 45

Soya and Linseed - 36

Source

http://www.the-gi-diet.org/lowgifoods/