New Inflammatory Index and ulcerative colitis

An August 2024 study by Chinese Medical Journals Publishing

• “Importantly, the assessment of activated immune cell infiltrations in the colonic lamina propria may provide a rationale for the precision diagnosis of histological healing in UC patients.”  

• “[The] inflammatory cell enumeration index (ICEI).’ Patients with lower values than the established ICEI threshold, and without crypt abscesses, mucin depletion, surface epithelial damage, and crypt architectural irregularities, were considered as having achieved tissue healing.”

• “As clinical therapy goals in UC continue to evolve, from endoscopic MH to histopathological healing, the ICEI offers a valuable tool for assessing and predicting the prognosis of UC patients. These advancements will definitely contribute to a deeper understanding of UC and offer opportunities for more tailored and effective management strategies.”

Chinese Medicine: Calorific Restriction and Heart Health

An April 2024 study reported in the Chinese Medical Journal, researchers said,

• “In experimental studies using murine models, the sirtuins, notably SIRT1, have been shown to mediate the beneficial effects of [Calorific Restriction] on diverse CVDs, including diabetic cardiomyopathy, myocardial ischemia–reperfusion injury, myocardial fibrosis, atherosclerosis, and abdominal aortic aneurysm,”

• “Existing studies on sirtuins and [Calorific Restriction] merely represent the tip of the iceberg. The evidence supporting sirtuins as a sensor or mediator of [Calorific Restriction] remains insufficient. The distinct functions of each molecule within the family have not been clearly analyzed. Moreover, the conclusions drawn from mouse experiments remain unclear, and further experiments in primates are yet to be conducted,”