An April 2024 study reported in the Chinese Medical Journal, researchers said,
“In experimental studies using murine models, the sirtuins, notably SIRT1, have been shown to mediate the beneficial effects of [Calorific Restriction] on diverse CVDs, including diabetic cardiomyopathy, myocardial ischemia–reperfusion injury, myocardial fibrosis, atherosclerosis, and abdominal aortic aneurysm,”
“Existing studies on sirtuins and [Calorific Restriction] merely represent the tip of the iceberg. The evidence supporting sirtuins as a sensor or mediator of [Calorific Restriction] remains insufficient. The distinct functions of each molecule within the family have not been clearly analyzed. Moreover, the conclusions drawn from mouse experiments remain unclear, and further experiments in primates are yet to be conducted,”