A May 2021 study by West Virginia University said,
"Stomach cancer is primarily caused by rampant inflammation,”
"The overarching theme of my lab is to understand what's controlling the balance between a protective immune response, which is just targeting the infection, and a pathogenic immune response, which is like a toddler throwing a temper tantrum and damaging everything. It looks like androgens may be really important in tipping that balance toward a protective response."
Glucocorticoids are "the chief anti-inflammatory hormones that your body produces …You can think of them as the brake pedal to the immune system.”
"We were able to completely rescue them from their stomach inflammation,”
"We proved that androgens were the hormones giving male mice that double layer of protection from inflammation. In the females, the only anti-inflammatory hormone was glucocorticoids. In males, it could be either glucocorticoids or androgens. This study potentially explains why women have a much higher incidence of autoimmune and chronic inflammatory diseases."
"Actually, eight out of 10 individuals with autoimmune disease are women,"
"If someone presents with stomach inflammation, it might be worth it for clinicians to investigate what's going on with their endocrine system,"
"Persistent, smoldering inflammation over the course of many, many years is the fertile ground for stomach cancer to grow."
"It's an important, and understudied, human health issue."
"These findings may help us understand how inflammation promotes cancer development, but we can't make any direct inferences about stomach cancer from this body of work,”
"That's the direction we're moving in, though. We're currently studying how sex affects carcinogenesis using an actual cancer model."