In a very interesting March 2021 study by the University of Otago it was said,
"Based on the results of laboratory testing, we identified the number of microRNAs that are impaired in stem cells of the diabetic heart”
"Among several microRNAs we identified that one particular microRNA called miR-30c - which is crucial for the stem cells' survival, growth and new blood vessel formation - is reduced in the diabetic stem cells. All these functions are required for stem cell therapy to be successful in the heart.
"Importantly, we also confirmed that this microRNA is decreased in the stem cells collected from the heart tissue of the patients undergoing heart surgery at Dunedin Hospital.”
A "simple injection” “…resulted in significantly improving the survival and growth of stem cells in the diabetic heart,"
"This fascinating discovery has newly identified that impairment in the microRNAs is the underlying reason for the stem cells being not functional in the diabetic heart. More importantly, the results have identified a novel therapy for activation of stem cells in the heart using microRNA, without the need to inject stem cells, which is a time and cost consuming process."
"Apart from identifying the reasons for poor stem cells function in a patient with diabetes, the novel therapy of using microRNA could change the treatment method for heart disease in diabetic individuals."
"Our initial analysis revealed that there might be another four potential candidate microRNAs. Therefore, it is essential to test the function of those microRNAs as well. It may be possible that combination therapy with more than one microRNA could further increase the beneficial effects."