A March 2020 study by the University of Southern California said,
"We tend to think human physiology is adapted to the conditions in which we evolved … So, we assumed that if inactivity is harmful, our evolutionary history would not have included much time spent sitting the way we do today."
"Even though there were long periods of inactivity, one of the key differences we noticed is that the Hadza [the group studied] are often resting in postures that require their muscles to maintain light levels of activity -- either in a squat or kneeling."
"Being a couch potato -- or even sitting in an office chair -- requires less muscle activity than squatting or kneeling … Since light levels of muscle activity require fuel, which generally means burning fats, then squatting and kneeling postures may not be as harmful as sitting in chairs."
“Preferences or behaviors that conserve energy have been key to our species' evolutionary success … But when environments change rapidly, these same preferences can lead to less optimal outcomes. Prolonged sitting is one example."
"Replacing chair sitting and associated muscular inactivity with more sustained active rest postures may represent a behavioral paradigm that should be explored in future experimental work."
"Squatting is not a likely alternative … but spending more time in postures that at least require some low-level muscle activity could be good for our health."