A March 2020 study by McMaster University, Université Laval, and the Québec Heart and Lung Institute said,
"Our findings suggest that in people suffering from severe obesity, bacteria or fragments of bacteria are associated with the development of type 2 diabetes,"
"We know that the intestinal barrier is more permeable in obese patients."
"Our hypothesis is that living bacteria and bacterial fragments cross this barrier and set off an inflammatory process that ultimately prevents insulin from doing its job, which is to regulate blood glucose levels by acting on metabolic tissues."
"Location, location location...Beyond knowing the names of bacteria, their location is key to understanding how gut microbes influence host metabolism."
"Our next objective is to determine if the bacteria found in the liver and fat deposits of people suffering from severe obesity are also present in those who are overweight or moderately obese."
"We also want to see if certain pathogenic bacteria found in the tissues can trigger type 2 diabetes in an animal model. And lastly, we want to find out if certain beneficial bacteria found in these tissues can be used to prevent the development of the disease. If so, they might lead us to a new family of probiotic bacteria or a source of bacteria-based treatments to help fight diabetes."