An October 2024 study of mice by University of Oklahoma College of Medicine said,
“We hypothesize that when liver necroptosis is activated, the liver secretes toxic or inflammatory molecules that enter the bloodstream and cross the blood-brain barrier, where they cause inflammation in the brain,”
“This type of organ crosstalk is becoming very important in research. Usually, when we study a disease condition, we focus on one organ, but when we do that, we miss the systemic effect.”
“This study tells us that, with age-associated cognitive decline or Alzheimer’s disease, we shouldn’t think only about targeting the brain. We also need to think about how liver inflammation plays a role,”
“What we have found in our mice studies so far matches what is reported for patients – that people with liver diseases have high inflammation in the liver and also have cognitive issues,”
“Our key question is what is causing this increase in inflammation in aging? It is important that we advance our knowledge in this area because it is critical that we develop new ways to treat these diseases.”