A March 2020 study by the University of Western Ontaria of sweet oranges and tangerines said,
"We went on to show that we can also intervene with nobiletin,"
"We've shown that in mice that already have all the negative symptoms of obesity, we can use nobelitin to reverse those symptoms, and even start to regress plaque build-up in the arteries, known as atherosclerosis."
"This result told us that nobiletin is not acting on AMP Kinase, and is bypassing this major regulator of how fat is used in the body,"
"What it still leaves us with is the question - how is nobiletin doing this?" [They don’t know yet].
“Obesity and its resulting metabolic syndromes are a huge burden to our health care system, and we have very few interventions that have been shown to work effectively… We need to continue this emphasis on the discovery of new therapeutics."